Services
Syncell Global Rapid Access Service Program (GRASP)
Syncell Microscoop™ enables microscopy-guided subcellular proteomics. It has helped identify novel proteomes of stress granules, β-amyloids, and other biological problems. Here Syncell announces its Global Rapid Access Service Program (GRASP) on a fee-for-service basis for researchers to gain access to the pioneering proteomic discovery platform to identify novel protein compositions or biomarkers at the subcellular regions of interest, such as immune synapses, focal adhesions, tips of primary cilia, peroxisomes, protein A-protein B colocalization sites, or any region one’s eyes can recognize under a microscope.
The expected result of a full GRASP service is a proteome at the target of one’s interest. Some novel protein players are expected to be revealed, with Microscoop’s high sensitivity and specificity. A researcher provides cell or tissue samples with microscopy-recognizable targets, and Microscoop’s fully automated ultrahigh-content directed photo-biotinylation facilitates subcellular protein isolation and subsequent proteome identification.
The expected result of a full GRASP service is a proteome at the target of one’s interest. Some novel protein players are expected to be revealed, with Microscoop’s high sensitivity and specificity. A researcher provides cell or tissue samples with microscopy-recognizable targets, and Microscoop’s fully automated ultrahigh-content directed photo-biotinylation facilitates subcellular protein isolation and subsequent proteome identification.
Service Options
From image pattern generation to an analysis of mass spectrometry results, the GRASP offers three different service options:
Option 1: Image pattern generation + Microscoop photolabeling + proteomic analysis
Option 1 provides an end-to-end spatial proteomics solution from a sample to a proteome. It includes algorithm development for image pattern generation (either using traditional image processing or AI-based image segmentation), Microscoop photo-biotinylation, protein enrichment, mass spectrometry, and proteomic analysis. Clients will receive a service report with the proteomic data that they can use as testable hypotheses for validation and functional studies.
Option 2: Image pattern generation + Microscoop photolabeling
Option 2 provides a solution for targeted protein enrichment by creating targeted photo-biotinylation. It includes algorithm development for image pattern generation (either using traditional image processing or AI-based image segmentation) and Microscoop photo-biotinylation. Syncell will mail the photolabeled samples back to the client. The client can then conduct protein enrichment and mass spectrometry analysis to identify the proteome from the targeted area on their own.
Option 3: Image pattern generation
Option 3 provides only the image pattern generation service to help the client develop an algorithm for image pattern generation either using traditional image processing or AI-based image segmentation. The algorithm or the trained neural network will then be provided to the client so that the client with a Microscoop system can call the algorithm or the neural network to perform Microscoop photolabeling on their own.
Microscoop™
Microscoop™ is the engine behind our GRASP service performing fully automated real-time microscopy-guided pattern illumination in ultrahigh content for large-scale protein photo-biotinylation and subsequent targeted protein isolation. It has been successfully used to discover novel proteomes for specific biological problems, including the identification of disease-associated biomarkers.
