Unveiling Novel Proteins at the Mitochondria-Lipid Droplet Interface: Insights from Microscopy-guided Spatial Proteomics
Webinar
Details
Mitochondria-lipid droplet (LD) contact sites play a crucial role in lipid metabolism and homeostasis. Dysregulation of this interaction has been linked to metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). Until recently, identifying novel protein components that regulate the dynamic interactions between mitochondria and LDs has been challenging. Gaining deeper insights into the molecular mechanics of the interactions of these organelles may provide insight into new therapeutic strategies for treating metabolic diseases.
Key Highlights
- Identification of novel proteins at mitochondria-lipid droplet contact sites using Microscoop® Mint and LC-MS/MS.
- Description of five novel molecular players not previously linked to lipid metabolism or mitochondrial function.
- Visualization of these putative proteins by immunofluorescence, demonstrating localization to mitochondria-lipid droplet contact sites.
- Functional validation of the actin-binding protein FHL3, and its impact on lipid droplet dynamics and mitochondrial structure.
- Deep dive into this cutting-edge proteomics approach for unbiased protein discovery in fixed tissues or cells.
Why Attend: Whether you are a seasoned researcher or new to the field of proteomics, this webinar offers invaluable insights into the unique capabilities and application of the Syncell Microscoop Mint. Don’t miss the opportunity to stay ahead in the ever-evolving world of spatial proteomics!
Speaker
Azad Gucwa, Ph.D
Senior Field Application Scientist
Syncell Inc.
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