The intricate network of proteins within the human body plays a critical role in maintaining health. Disruptions in this system can lead to the development of various diseases, particularly when misfolded proteins disrupt cellular functions. The accumulation of these misfolded protein aggregates is a hallmark of neurodegenerative diseases such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and Huntington's disease. These aggregates are known to contribute to the formation of toxic cellular environment, ultimately driving disease progression. Diseases characterized by protein aggregates pose significant challenges in biomedical research. For instance, in Alzheimer's disease, β-amyloid plaques and tau tangles accumulate within the brain, disrupting neuronal communication and leading to cognitive decline. Similarly, in Parkinson's disease, α-synuclein aggregates known as Lewy bodies develop within neurons, contributing to the motor symptoms and neurodegeneration characteristic of the disease. Cardiac amyloidosis arises from the accumulation of misfolded proteins in the heart, impairing its ability to pump effectively, which can lead to heart failure and death. From the neurodegenerative Alzheimer's to the insidious growth of protein deposits in heart failure, understanding the specific proteins involved in these aggregates is a fundamental step towards developing effective treatments.
Info@syncell.com | |
617-631-2746 | |
200 Dexter Ave, Watertown, MA 02472, USA | |
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The intricate network of proteins within the human body plays a critical role in maintaining health. Disruptions in this system can lead to the development of various diseases, particularly when misfolded proteins disrupt cellular functions. The accumulation of these misfolded protein aggregates is a hallmark of neurodegenerative diseases such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and Huntington's disease. These aggregates are known to contribute to the formation of toxic cellular environment, ultimately driving disease progression. Diseases characterized by protein aggregates pose significant challenges in biomedical research. For instance, in Alzheimer's disease, β-amyloid plaques and tau tangles accumulate within the brain, disrupting neuronal communication and leading to cognitive decline. Similarly, in Parkinson's disease, α-synuclein aggregates known as Lewy bodies develop within neurons, contributing to the motor symptoms and neurodegeneration characteristic of the disease. Cardiac amyloidosis arises from the accumulation of misfolded proteins in the heart, impairing its ability to pump effectively, which can lead to heart failure and death. From the neurodegenerative Alzheimer's to the insidious growth of protein deposits in heart failure, understanding the specific proteins involved in these aggregates is a fundamental step towards developing effective treatments.
Info@syncell.com | |
+886-2-2785-6780 | |
200 Dexter Ave, Watertown, MA 02472, USA | |
|